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ED Treatment | VIAGRA® (sildenafil citrate) | Safety Info

Publication date: 2018-05-18 22:05

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Cardiovascular: angina pectoris, AV block, migraine, syncope, tachycardia, palpitation, hypotension, postural hypotension, myocardial ischemia, cerebral thrombosis, cardiac arrest, heart failure, abnormal electrocardiogram, cardiomyopathy.

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In a drug-drug interaction study sildenafil 55 mg given with alcohol g/kg in which mean maximum blood alcohol levels of % was achieved, sildenafil did not potentiate the hypotensive effect of alcohol in healthy volunteers [see CLINICAL PHARMACOLOGY ].

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Inactive ingredients: microcrystalline cellulose, anhydrous dibasic calcium phosphate, croscarmellose sodium, magnesium stearate, hypromellose, titanium dioxide, lactose, triacetin, and FD & C Blue #7 aluminum lake

Frequently Asked Questions VIAGRA® (sildenafil citrate

The safety and efficacy of combinations of VIAGRA with other PDE5 Inhibitors, including REVATIO or other pulmonary arterial hypertension ( PAH ) treatments containing sildenafil, or other treatments for erectile dysfunction have not been studied. Such combinations may further lower blood pressure. Therefore, the use of such combinations is not recommended.

VIAGRA does not protect you or your partner from getting sexually transmitted diseases, including HIV the virus that causes AIDS.

In many of the studies, of both fixed dose and titration designs, daily diaries were kept by patients. In these studies, involving about 6655 patients, analyses of patient diaries showed no effect of Viagra on rates of attempted intercourse (about 7 per week), but there was clear treatment-related improvement in sexual function: per patient weekly success rates averaged on 55&ndash 655 mg of Viagra vs on placebo similarly, group mean success rates (total successes divided by total attempts) were about 66% on Viagra vs about 75% on placebo.

In studies with healthy volunteers of single doses up to 855 mg, adverse reactions were similar to those seen at lower doses but incidence rates and severities were increased.

Based upon measurements of sildenafil in semen of healthy volunteers 95 minutes after dosing, less than % of the administered dose may appear in the semen of patients.

There are no controlled clinical data on the safety or efficacy of Viagra in patients with retinitis pigmentosa (a minority of these patients have genetic disorders of retinal phosphodiesterases) if prescribed, this should be done with caution.

No dose adjustment is required for mild (CLcr=55-85 mL/min) and moderate (CLcr=85-99 mL/min) renal impairment. In volunteers with severe renal impairment (Clcr 85 mL/min), sildenafil clearance was reduced, resulting in higher plasma exposure of sildenafil (~7 fold), approximately doubling of Cmax and AUC. A starting dose of 75 mg should be considered in patients with severe renal impairment [see DOSAGE AND ADMINISTRATION and CLINICAL PHARMACOLOGY ].

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ED Treatment | VIAGRA® (sildenafil citrate) | Safety Info Viagra 50 mg use

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