Publication date: 2018-05-01 01:17
In rare instances, men taking PDE5 inhibitors (oral erectile dysfunction medicines, including Levitra) reported a sudden decrease or loss of vision in one or both eyes. It is uncertain whether PDE5 inhibitors directly cause the vision loss. If you experience sudden decrease or loss of vision, stop taking PDE5 inhibitors, including Levitra, and call a doctor right away.
Levitra offers may be in the form of a printable coupon, rebate, savings card, trial offer, or free samples. Some offers may be printed right from a website, others require registration, completing a questionnaire, or obtaining a sample from the doctor's office.
Prior to initiating any treatment for erectile dysfunction, physicians should consider the cardiovascular status of their patients, since there is a degree of cardiac risk associated with sexual activity (see section ). Vardenafil has vasodilator properties, resulting in mild and transient decreases in blood pressure (see section ). Patients with left ventricular outflow obstruction, ., aortic stenosis and idiopathic hypertrophic subaortic stenosis, can be sensitive to the action of vasodilators including Type 5 phosphodiesterase inhibitors.
Inform patients that in some patients concomitant use of PDE5 inhibitors, including Levitra, with alpha-blockers can lower blood pressure significantly leading to symptomatic hypotension (for example, fainting). Patients prescribed Levitra who are taking alpha-blockers should be started on the lowest recommended starting dose of Levitra [see Dosage and Administration ( ) and Drug Interactions ( 7 )]. Patients should be advised of the possible occurrence of symptoms related to postural hypotension and appropriate countermeasures. Patients should be advised to contact the prescribing physician if other anti-hypertensive drugs or new medications that may interact with Levitra are prescribed by another healthcare provider.
Levitra has not been evaluated in patients with known hereditary degenerative retinal disorders, including retinitis pigmentosa, therefore its use is not recommended until further information is available in those patients.
When vardenafil film-coated tablets are taken with a high fat meal (containing 57% fat), the rate of absorption is reduced, with an increase in the median t max of 6 hour and a mean reduction in C max of 75%. Vardenafil AUC is not affected. After a meal containing 85% fat, the rate and extent of absorption of vardenafil (t max , C max and AUC) are unchanged compared to administration under fasting conditions.
Ritonavir and Indinavir: Upon concomitant administration of 5 mg of Levitra with 655 mg BID ritonavir, the C max and AUC of ritonavir were reduced by approximately 75%. Upon administration of 65 mg of Levitra with 855 mg TID indinavir, the C max and AUC of indinavir were reduced by 95% and 85%, respectively.
They are also encouraging customers to fill a small bag with winter clothes they no longer need and drop it off at one of their restaurants.
Other interactions: Levitra had no effect on the pharmacodynamics of glyburide (glucose and insulin concentrations) and warfarin (prothrombin time or other pharmacodynamic parameters).