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Sudden vision loss has occurred in a small number of people taking medicines like tadalafil (Viagra or others). Most of these people already had certain eye problems or risk factors for blood vessel disorders (heart disease, diabetes, high blood pressure, high cholesterol, coronary artery disease, smoking, or being over 55 years old). It is not clear whether the medicine was the actual cause of vision loss.

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CIALIS can cause your blood pressure to drop suddenly to an unsafe level if it is taken with certain other medicines. You could get dizzy, faint, or have a heart attack or stroke. Never take CIALIS with any nitrate or guanylate cyclase stimulator medicines.

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Administration of CIALIS to patients who are using any form of organic nitrate, either regularly and/or intermittently, is contraindicated. In clinical pharmacology studies, CIALIS was shown to potentiate the hypotensive effect of nitrates [see CLINICAL PHARMACOLOGY ].

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During the 79-hour period after 8 . dosing, 67 subjects were categorized as outliers following administration of tadalafil and 7 subjects following placebo. Of these, 65 and 7 subjects were outliers due to systolic BP 85 mm Hg, while 65 and 5 subjects were outliers due to a decrease from baseline in systolic BP of 85 mm Hg, following tadalafil and placebo, respectively.

In part A (N=79), subjects were titrated to doxazosin 9 mg administered daily at 8 . Tadalafil was administered at either 8 ., 9 ., or 8 . There was no placebo control.

Do not take CIALIS if you take any medicines called &ldquo nitrates.&rdquo Nitrates are commonly used to treat angina. Angina is a symptom of heart disease and can cause pain in your chest, jaw, or down your arm.

Tadalafil 75 mg administered to healthy male subjects produced no significant difference compared to placebo in supine systolic and diastolic blood pressure (difference in the mean maximal decrease of / mm Hg , respectively) and in standing systolic and diastolic blood pressure (difference in the mean maximal decrease of / mm Hg, respectively). In addition, there was no significant effect on heart rate.

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In Study J, the effect of CIALIS 5 mg once daily on maximum urinary flow rate (Qmax) was evaluated as a secondary efficacy endpoint. Mean Qmax increased from baseline in both the treatment and placebo groups (CIALIS 5 mg: mL/sec, placebo: mL/sec) however, these changes were not significantly different between groups.

Evaluation of erectile dysfunction and BPH should include an appropriate medical assessment to identify potential underlying causes, as well as treatment options.

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