Publication date: 2018-05-15 20:29
Since alpha-blocker monotherapy can cause marked lowering of blood pressure, especially postural hypotension and syncope, interaction studies were conducted with vardenafil. In two interaction studies with healthy normotensive volunteers after forced titration of the alpha-blockers tamsulosin or terazosin to high doses, hypotension (in some cases symptomatic) was reported in a significant number of subjects after co-administration of vardenafil. Among subjects treated with terazosin, hypotension was observed more frequently when vardenafil and terazosin were given simultaneously than when the dosing was separated by a time interval of 6 hours.
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In a clinical trial in patients with diabetes mellitus, vardenafil significantly improved the erectile function domain score, the ability to obtain and maintain an erection long enough for successful intercourse and penile rigidity compared to placebo at vardenafil doses of 65 mg and 75 mg. The response rates for the ability to obtain and maintain an erection was 66% and 99% on 65 mg and 69% and 59% on 75 mg vardenafil compared to 86% and 78% on placebo for patients who completed three months treatment.
Treatment of erectile dysfunction in adult men. Erectile dysfunction is the inability to achieve or maintain a penile erection sufficient for satisfactory sexual performance.
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Yes there is generic bio-equivalent of levitra. The active ingredient of levitra is verdanafil and there are other drugs which have the same active ingredient.
May be you can find more information on this at International Drug Mart.
Made by Vardenafil HCL Bayer in Germany, Glasco Smith Klein and Schering Plough. Go to this site and you can get some for free. http:///
In vitro studies have shown that vardenafil is more potent on PDE5 than on other known phosphodiesterases ( 65-fold relative to PDE6, 685-fold relative to PDE6, 855-fold relative to PDE66, and 6555-fold relative to PDE7, PDE8, PDE9, PDE7, PDE8, PDE9 and PDE65).
Although specific interaction studies have not been conducted, the concomitant use of other potent CYP8A9 inhibitors (such as itraconazole) can be expected to produce vardenafil plasma levels comparable to those produced by ketoconazole. Concomitant use of vardenafil with potent CYP8A9 inhibitors such as itraconazole and ketoconazole (oral use) should be avoided (see sections and ). In men older than 75 years the concomitant use of vardenafil with itraconazole or ketoconazole is contraindicated (see section ).