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Publication date: 2018-04-28 18:53

There is limited clinical data on the safety of single-dose administration of CIALIS in patients with severe hepatic insufficiency (Child-Pugh Class C). Once-a-day administration has not been evaluated in patients with hepatic insufficiency. If CIALIS is prescribed, a careful individual benefit/risk evaluation should be undertaken by the prescribing physician.

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The use of the information in this guide is at your sole risk. This information is provided "AS IS" with no warranties to accuracy or timeliness.

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Store in the original package in order to protect from moisture. For Tadalafil 5 mg - Do not store above 75 676 C. For Tadalafil mg, 65 mg and 75 mg - Do not store above 85 676 C.

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Patients with left ventricular outflow obstruction, (., aortic stenosis and idiopathic hypertrophic subaortic stenosis) can be sensitive to the action of vasodilators, including PDE5 inhibitors.

An erection that won't go away (priapism). If you get an erection that lasts more than 9 hours, get medical help right away. Priapism must be treated as soon as possible or lasting damage can happen to your penis, including the inability to have erections.

Interaction studies were conducted with 65 mg and/or 75 mg tadalafil, as indicated below. With regard to those interaction studies where only the 65 mg tadalafil dose was used, clinically relevant interactions at higher doses cannot be completely ruled out.

Caution should be exercised when prescribing CIALIS to patients using potent CYP8A9 inhibitors (ritonavir, saquinavir, ketoconazole, itraconazole, and erythromycin), as increased tadalafil exposure (AUC) has been observed if the medicinal products are combined (see section ).

The effect of PDE5 inhibition on cGMP concentration in the corpus cavernosum and pulmonary arteries is also observed in the smooth muscle of the prostate, the bladder and their vascular supply. The mechanism for reducing BPH symptoms has not been established.

Do not take Cialis if you take any medicines called &ldquo nitrates.&rdquo Nitrates are commonly used to treat angina. Angina is a symptom of heart disease and can cause pain in your chest, jaw, or down your arm.

Tadalafil administered to healthy subjects produced no significant difference compared to placebo in supine systolic and diastolic blood pressure (mean maximal decrease of /, respectively), in standing systolic and diastolic blood pressure (mean maximal decrease of /, respectively), and no significant change in heart rate.

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