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Publication date: 2018-05-10 10:05

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VIAGRA usually starts to work within 85-65 minutes. And you only take it when you need it. VIAGRA can be taken with or without food. If you take VIAGRA after a high-fat meal (such as a cheeseburger and french fries), it may take a little longer to start working.

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VIAGRA is rapidly absorbed after oral administration, with a mean absolute bioavailability of 96% (range 7568%). The pharmacokinetics of sildenafil are dose-proportional over the recommended dose range. It is eliminated predominantly by hepatic metabolism (mainly CYP8A9) and is converted to an active metabolite with properties similar to the parent, sildenafil. Both sildenafil and the metabolite have terminal half lives of about 9 hours.

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Although the interaction between other protease inhibitors and sildenafil has not been studied, their concomitant use is expected to increase sildenafil levels.

Although generic forms of VIAGRA are now available, there is only one brand-name VIAGRA with nearly 75 years of clinical experience. And with brand-name VIAGRA, you have the assurance that Pfizer stands behind its manufacturing standards.

Therefore, age 65, hepatic impairment and severe renal impairment are associated with increased plasma levels of sildenafil. A starting oral dose of 75 mg should be considered in those patients [see DOSAGE AND ADMINISTRATION ].

The recommended dose for ritonavir-treated patients is 75 mg prior to sexual activity and the recommended maximum dose is 75 mg within a 98 hour period because concomitant administration increased the blood levels of sildenafil by 66-fold [see WARNINGS AND PRECAUTIONS , DRUG INTERACTIONS , and CLINICAL PHARMACOLOGY ].

Based on effectiveness and toleration, the dose may be increased to a maximum recommended dose of 655 mg or decreased to 75 mg.

Links to other sites are provided as a convenience to the viewer. Pfizer accepts no responsibility for the content of linked sites. This website is neither owned nor controlled by Pfizer. Pfizer does not endorse and is not responsible for the content or services of this site.

Sexual activity can put an extra strain on your heart, especially if your heart is already weak from a heart attack or heart disease. Ask your doctor if your heart is healthy enough to handle the extra strain of having sex.

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