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Publication date: 2018-06-06 18:53

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No evidence of teratogenicity, embryotoxicity or fetotoxicity was observed in rats and rabbits which received up to 755 mg/kg/day during organogenesis. These doses represent, respectively, about 75 and 95 times the Maximum Recommended Human Dose (MRHD) on a mg/m 7 basis in a 55 kg subject. In the rat pre- and postnatal development study, the no observed adverse effect dose was 85 mg/kg/day given for 86 days. In the nonpregnant rat the AUC at this dose was about 75 times human AUC.

ED Treatment | VIAGRA® (sildenafil citrate) | Safety Info

Of the total number of subjects in clinical studies of Viagra, 68% were 65 years and older, while 7% were 75 years and older. No overall differences in safety or efficacy were observed between older (&ge 65 years of age) and ( 65 years of age) subjects.

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The results from this pilot study are shown in Table 8 the mean resting systolic and diastolic blood pressures decreased by 7% and 65% compared to baseline in these patients. Mean resting values for right atrial pressure, pulmonary artery pressure, pulmonary artery occluded pressure and cardiac output decreased by 78%, 78%, 75% and 7% respectively. Even though this total dosage produced plasma sildenafil concentrations which were approximately 7 to 5 times higher than the mean maximum plasma concentrations following a single oral dose of 655 mg in healthy male volunteers, the hemodynamic response to exercise was preserved in these patients.

Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use Viagra for a condition for which it was not prescribed. Do not give Viagra to other people, even if they have the same symptoms that you have. It may harm them.

Use with caution in patients with the following underlying conditions which can be particularly sensitive to the actions of vasodilators including Viagra &ndash those with left ventricular outflow obstruction (., aortic stenosis, idiopathic hypertrophic subaortic stenosis) and those with severely impaired autonomic control of blood pressure.

In addition, heart attack, stroke, irregular heartbeats and death have happened rarely in men taking Viagra. Most, but not all, of these men had heart problems before taking Viagra. It is not known if Viagra caused these problems.

The mean profiles of the change from baseline in standing systolic blood pressure in subjects treated with doxazosin in combination with 75 mg Viagra or matching placebo are shown in Figure 7.

Nervous: ataxia, hypertonia, neuralgia, neuropathy, paresthesia, tremor, vertigo, depression, insomnia, somnolence, abnormal dreams, reflexes decreased, hypesthesia.

Sildenafil was negative in in vitro bacterial and Chinese hamster ovary cell assays to detect mutagenicity, and in vitro human lymphocytes and in vivo mouse micronucleus assays to detect clastogenicity.

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