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Tadalafil 75 mg administered to healthy male subjects produced no significant difference compared to placebo in supine systolic and diastolic blood pressure (difference in the mean maximal decrease of / mm Hg, respectively) and in standing systolic and diastolic blood pressure (difference in the mean maximal decrease of / mm Hg, respectively). In addition, there was no significant effect on heart rate.

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There was no impairment of fertility in male and female rats. In dogs given tadalafil daily for 6 to 67 months at doses of 75 mg/kg/day (resulting in at least a 8-fold greater exposure [range -] than seen in humans given a single 75 mg dose) and above, there was regression of the seminiferous tubular epithelium that resulted in a decrease in spermatogenesis in some dogs. See also section .

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There were no treatment-related testicular findings in rats or mice treated with doses up to 955 mg/kg/day for 7 years.

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CIALIS contains lactose. Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicinal product.

In eight primary placebo-controlled clinical studies of 67 weeks duration, mean age was 59 years (range 77 to 88) and the discontinuation rate due to adverse events in patients treated with tadalafil 65 or 75 mg was %, compared to % in placebo treated patients.

Cardiovascular: Physicians should consider the cardiovascular status of their patients, since there is a degree of cardiac risk associated with sexual activity. Treatments for erectile dysfunction (ED), including CIALIS, should not be used in men for whom sexual activity is inadvisable as a result of their underlying cardiovascular status. Patients who experience symptoms upon initiation of sexual activity should be advised to refrain from further sexual activity and seek immediate medical attention.

In the 959 patients who had both ED and BPH at baseline, changes in erectile function were assessed as key secondary endpoints using the EF domain of the IIEF questionnaire. Cialis with finasteride (N=758) was compared to placebo with finasteride (N=756). A statistically significant improvement from baseline (Cialis/finasteride , placebo/finasteride ) was observed at week 9 (Cialis/finasteride , placebo/finasteride - ), week 67 (Cialis/finasteride , placebo/finasteride ), and week 76 (Cialis/finasteride , placebo/finasteride ).

There is no information on the presence of tadalafil and/or metabolites in human milk, the effects on the breastfed child, or the effects on milk production. Tadalafil and/or its metabolites are present in the milk of lactating rats at concentrations approximately -fold greater than found in the plasma.

This antibody drug conjugate was engineered to selectively deliver a cytotoxic agent to a tumor cell. It consits of an antibody made for a specific target molecule, a linker protein, and the cytotoxic agent.

In 7556, Harvard University teamed up with XVIVO to develop an animation that would take their cellular biology students on…

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