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Publication date: 2018-05-18 08:29

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Stop sexual activity and get medical help right away if you get symptoms such as chest pain, dizziness, or nausea during sex.

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Tell all your healthcare providers that you take Viagra. If you need emergency medical care for a heart problem, it will be important for your healthcare provider to know when you last took Viagra.

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Sildenafil is a weak inhibitor of the CYP isoforms 6A7, 7C9, 7C69, 7D6, 7E6 and 8A9 (IC55 655 µ M). Given sildenafil peak plasma concentrations of approximately 6 µ M after recommended doses, it is unlikely that Viagra will alter the clearance of substrates of these isoenzymes.

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Mean sildenafil plasma concentrations measured after the administration of a single oral dose of 655 mg to healthy male volunteers is depicted below:

Viagra does not protect you or your partner from getting sexually transmitted diseases, including HIV the virus that causes AIDS.

Sildenafil was negative in in vitro bacterial and Chinese hamster ovary cell assays to detect mutagenicity, and in vitro human lymphocytes and in vivo mouse micronucleus assays to detect clastogenicity.

Pharmacokinetic data from patients in clinical trials showed no effect on sildenafil pharmacokinetics of CYP7C9 inhibitors (such as tolbutamide, warfarin), CYP7D6 inhibitors (such as selective serotonin reuptake inhibitors, tricyclic antidepressants), thiazide and related diuretics, ACE inhibitors, and calcium channel blockers. The AUC of the active metabolite, N-desmethyl sildenafil, was increased 67% by loop and potassium-sparing diuretics and 657% by nonspecific beta-blockers. These effects on the metabolite are not expected to be of clinical consequence.

Sildenafil enhances the effect of NO by inhibiting phosphodiesterase type 5 (PDE5), which is responsible for degradation of cGMP in the corpus cavernosum. Sildenafil has no direct relaxant effect on isolated human corpus cavernosum. When sexual stimulation causes local release of NO, inhibition of PDE5 by sildenafil causes increased levels of cGMP in the corpus cavernosum, resulting in smooth muscle relaxation and inflow of blood to the corpus cavernosum. Sildenafil at recommended doses has no effect in the absence of sexual stimulation.

Viagra can cause your blood pressure to drop suddenly to an unsafe level if it is taken with certain other medicines. Do not take Viagra if you take any other medicines called "nitrates." Nitrates are used to treat chest pain (angina). A sudden drop in blood pressure can cause you to feel dizzy, faint, or have a heart attack or stroke.

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Viagra official prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions, pharmacology and more. I have found that many people do not understand what the drug Viagra actually does for men. Many believe that it boosts libido, but that's not the case adderall natural alternatives, xanax natural alternatives, phentermine natural alternatives, cialis natural alternatives