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Physicians should inform patients not to take VIAGRA with other PDE5 inhibitors including REVATIO or other pulmonary arterial hypertension (PAH) treatments containing sildenafil. Sildenafil is also marketed as REVATIO for the treatment of PAH. The safety and efficacy of VIAGRA with other PDE5 inhibitors, including REVATIO, have not been studied [see WARNINGS AND PRECAUTIONS ].

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Across all trials, VIAGRA improved the erections of 98% of radical prostatectomy patients compared to 65% on placebo.

How Does VIAGRA® (sildenafil citrate) Work? | Safety Info

Three double-blind, placebo-controlled, randomized, two-way crossover studies were conducted to assess the interaction of VIAGRA with doxazosin, an alpha-adrenergic blocking agent.

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VIAGRA is rapidly absorbed. Maximum observed plasma concentrations are reached within 85 to 675 minutes (median 65 minutes) of oral dosing in the fasted state. When VIAGRA is taken with a high fat meal, the rate of absorption is reduced, with a mean delay in Tmax of 65 minutes and a mean reduction in Cmax of 79%. The mean steady state volume of distribution (Vss) for sildenafil is 655 L, indicating distribution into the tissues. Sildenafil and its major circulating N-desmethyl metabolite are both approximately 96% bound to plasma proteins. Protein binding is independent of total drug concentrations.

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The physiologic mechanism of erection of the penis involves release of nitric oxide (NO) in the corpus cavernosum during sexual stimulation. NO then activates the enzyme guanylate cyclase, which results in increased levels of cyclic guanosine monophosphate (cGMP), producing smooth muscle relaxation in the corpus cavernosum and allowing inflow of blood.

VIAGRA is supplied as blue, film-coated, rounded-diamond-shaped tablets containing sildenafil citrate equivalent to 75 mg, 55 mg, or 655 mg of sildenafil. Tablets are debossed with PFIZER on one side and VGR75, VGR55 or VGR655 on the other to indicate the dosage strengths.

The length of time Viagra lasts for will also vary from person to person, but it has been known to work for up to 5 hours at a time, when used alongside sexual stimulation. Most men will find, however, that the effects of the pill will start to wear off 7-8 hours after first taking it.

Diabetes is a condition where there is too much sugar, or glucose, in the blood. Over time, high blood sugar levels can damage nerves and blood vessels—like the ones that produce erections. When this occurs, diabetes can lead to ED.

In fixed-dose studies, the incidence of some adverse reactions increased with dose. The type of adverse reactions in flexible-dose studies, which reflect the recommended dosage regimen, was similar to that for fixed-dose studies. At doses above the recommended dose range, adverse reactions were similar to those detailed in Table 6 below but generally were reported more frequently.

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